Kutsitsimutsanso kwa Latent HIV-1 Infection ndi Periodontopathic Bacterium

Ma cell omwe ali ndi kachilomboka amakhala ndi kachilombo ka HIV-1 proviral DNA genome makamaka ophatikizidwa mu heterochromatin, zomwe zimalola kulimbikira kwa ma provirus osalankhula.Hypoacetylation of histone proteins by histone deacetylases (HDAC) imakhudzidwa ndi kusungidwa kwa latency ya HIV-1 poletsa kulembedwa kwa ma virus.Kuphatikiza apo, matenda a periodontal, omwe amayamba chifukwa cha mabakiteriya a polymicrobial subgingival kuphatikiza Porphyromonas gingivalis, ndi ena mwa matenda omwe afala kwambiri mwa anthu.Apa tikuwonetsa zotsatira za P. gingivalis pa HIV-1 kubwerezabwereza.Izi zitha kukhala zogwirizana ndi chikhalidwe cha bakiteriya choposa mphamvu koma osati mabakiteriya ena monga fimbriae kapena LPS.Tidapeza kuti ntchito yoyambitsa kachilombo ka HIV-1 idapezedwanso m'gawo laling'ono la molekyulu (<3 kDa) la chikhalidwe champhamvu kwambiri.Tidawonetsanso kuti P. gingivalis imapanga kuchuluka kwa butyric acid, yomwe imakhala ngati inhibitor yamphamvu ya HDACs ndikupangitsa histone acetylation.Chromatin immunoprecipitation assays adawonetsa kuti corepressor complex yomwe ili ndi HDAC1 ndi AP-4 idasiyanitsidwa ndi wolimbikitsa wobwereza wautali wa HIV-1 atakondoweza ndi chikhalidwe cha bakiteriya chopambana kwambiri ndi mgwirizano wa acetylated histone ndi RNA polymerase II.Choncho tinapeza kuti P. gingivalis angapangitse kuti kachilombo ka HIV-1 kuyambitsidwenso kudzera mu kusintha kwa chromatin ndi kuti butyric acid, imodzi mwa metabolites ya bakiteriya, ndiyo yomwe imayambitsa izi.Zotsatirazi zikuwonetsa kuti matenda a periodontal amatha kukhala pachiwopsezo choyambitsanso kachilombo ka HIV-1 mwa anthu omwe ali ndi kachilomboka ndipo amathandizira kufalitsa kachilomboka.