Ndi (1-3)-β-D-glucan Ulalo Wosowa kuchokera ku Bedside Assessment kupita ku Pre-emptive Therapy of Invasive

Invasive candidiasis ndizovuta zomwe zimawopseza moyo kwa odwala omwe akudwala kwambiri.Kuzindikira koyambirira kotsatiridwa ndi chithandizo chachangu chomwe cholinga chake ndi kuwongolera zotsatira zake pochepetsa kugwiritsa ntchito mankhwala oletsa tizilombo toyambitsa matenda osafunikira kumakhalabe vuto lalikulu mu ICU.Kusankhidwa kwa odwala panthawi yake kumagwira ntchito yofunika kwambiri pazachipatala komanso kasamalidwe kabwino.Njira zophatikizira zowopsa zachipatala ndi data ya Candida colonization yatithandiza kuzindikira odwala otere msanga.Ngakhale kuti mtengo wolosera wolakwika wa ziwerengero ndi malamulo olosera ukukwera mpaka 95 mpaka 99%, mtengo wolosera wabwino ndi wotsika kwambiri, kuyambira 10 mpaka 60%.Chifukwa chake, ngati chiwongola dzanja chabwino kapena lamulo likugwiritsidwa ntchito kutsogolera kuyambika kwa mankhwala a antifungal, odwala ambiri amatha kuthandizidwa mosafunikira.Ma biomarkers a Candida amawonetsa zolosera zabwino kwambiri;komabe, alibe chidwi ndipo sangathe kuzindikira zochitika zonse za candidiasis.The (1-3) -β-D-glucan (BG) assay, panfungal antigen test, akulimbikitsidwa ngati chida chothandizira kuti azindikire za mycoses zowonongeka kwa odwala omwe ali ndi chiopsezo chachikulu cha hemato-oncological.Udindo wake pakuchulukirachulukira kwa anthu a ICU uyenera kufotokozedwa.Njira zogwirira ntchito zosankhidwa bwino zachipatala pamodzi ndi zida za labotale zomwe zimagwira ntchito ndizofunikira kuti athe kuchiza odwala oyenera panthawi yoyenera posunga ndalama zowunikira komanso chithandizo chochepa momwe zingathere.Njira yatsopano yoperekedwa ndi Posteraro ndi anzake m'nkhani yapitayi ya Critical Care ikukwaniritsa zofunikirazi.Phindu limodzi labwino la BG mwa odwala omwe adavomerezedwa ku ICU ndi sepsis ndipo akuyembekezeka kukhala masiku opitilira 5 asanachitike zolemba za candidiasis ndi masiku 1 mpaka 3 ndi kulondola komwe sikunachitikepo.Kugwiritsa ntchito kuwunika kwa mafangasi amodzi pagawo losankhidwa la odwala a ICU omwe ali ndi chiopsezo cha 15 mpaka 20% chokhala ndi candidiasis ndi njira yosangalatsa komanso yotsika mtengo.Ngati kutsimikiziridwa ndi kafukufuku wambiri, ndikuperekedwa kwa odwala opaleshoni omwe ali pachiopsezo chachikulu cha candidiasis pambuyo pa opaleshoni ya m'mimba, njira iyi ya Bayesian yokhazikitsidwa ndi chiopsezo chofuna kupititsa patsogolo ntchito zachipatala mwa kuchepetsa kugwiritsa ntchito chithandizo chamankhwala kungathandize kwambiri kasamalidwe ka odwala omwe ali pangozi. matenda a candidiasis.